Quite apart from the roostock factor most fruit trees (in the simple sense of apples,pears etc) are grafted so one can be sure of the end result fruit type... few will come true from seed.... unless you get into tropical stuff like mango with polyembryonic seeds so you get a mix of parent and hybrid germinations despite cross pollination (I think)
I had a problem in my last place with 2 walnut trees that suddenly showed signs of disease - black mottling on the leaves. At that time i spoke to an expert at an agricultural college who was bemoaning the clean air and lck of cola and sulphur pollution which kept most fungal diseases at bay (good for the trees but bad for the kids) - he claimed that was why a lot of the victorian roses did so well and don't now.
As it happens those trees self-cured after about 2 years but during my research i was intersted to find that there are injectable systemic therapies for some tree diseases.
Now if you want to grow soemthig big and can affort a 60foot high greenhouse then try beadfruit
- huge beautiful trees full of tasty bounty. I'm mad enough to have actually tried to grow some root cuttings I smuggled in years ago.. probably as well they failed...
The problem with giant trees is both picking fruit and treating disease - frankly not worth it.
You probbaly know from my previous posts that I promote the idea of espaliers for ease of looking after.. you can try grwoing soem vigorous varieties that way and go for wide spreads rather than heights if prepared for the first several years shaping it all. Or stay sane with sensible size trees and just more variety and numbers just like the commercial guys.