It is curious that the LA version does not give a contraindication but the 1% solution dose does. The difference in drug concentration max is probably the factor though I suppose it is possible it is an excipient causing the problem. Intuitively I would avoid a LA formulation of a drug giving a reaction as an immediate release, not least of all because there is a longer period for the adverse event to happen but from your communication [member=2128]Womble[/member] this has been properly investigated in this case.