I have done it, mainly because I couldn't keep dog and bitch separate, and along time ago - no ill effects at all and normal seasons after they stopped, plus normal whelping too. And the drugs are much refined since then. Not sure |I'd take the chance again though.
However, you need to be absolutely sure there is no other way, and the timing may be crucial - if she is almost in season now or already in season it can muck up their hormones even more, so think about it, research, don't rush into it tomorrow or next week, and make an informed decision.