The issue with ivermectin based products is withdrawal. I rear birds for eggs and meat and prefer not to apply anything more than DE directly to the bird. Im not sure the research has been done (officially) on whether ivermectin gets into the eggs ( my guess is yes, via preening) and so I would rather go down a less chemical route in terms of what I put on the hens.
Ultimately, and this will probably stir a lot of protest, serious red mite infestation is down to poor husbandry. If you check and recheck housing frequently, then you will spot an infestation before it becomes nasty and therefor have an opportunity to nip it in the bud. Too often I have been informed by hen keepers that their hens have died from heavy infestation of red mite. Given that the main symptoms are fewer/no eggs, paler than usual combs, excessive dust bathing and preening, I would have thought that these symptoms alone would alert someone that something is amiss.
It is all about observation, as in any animal. Unfortunately the poor old farmyard hen, being relatively cheap to keep compared to larger animals, often gets overlooked.