Reading that info sheet, Mammyshaz, it does say that early spaying of large breeds is not advised. In particular, those breeds which are prone to osteosarcoma and/or joint problems. And also to be avoided in dogs which will be very active - canicross, agility, etc, and presumeably working dogs too.
Our Veni, one of the pair that was spayed before their first season, was a total mongrel but similar size and shape to a Doberman. We had her put to sleep, aged 10, when she developed a tumour in her elbow.
She had had painful joints from about 3 years old, with no medical reason ever having been found. We had to give her several short walks a day, rather than one big one, and mainly walks where she would amble rather than run about. If we were doing a long walk, and/or asking her to be very active - running and jumping - then we had to make sure she had a good warm up before being very energetic, and warm down after. (She was a very happy, boisterous and playful dog in general, but did get stiff and sore if we didn't heed this advice.)